2022
Sun Y, Pinto C, Camus S, Duval V, Alayrac P, Zlatanova I, Loyer X, Vilar J, Lemitre M, Levoye A, Nus M, Ait-Oufella H, Mallat Z, Silvestre JS. Splenic Marginal Zone B Lymphocytes Regulate Cardiac Remodeling After Acute Myocardial Infarction in Mice. J Am Coll Cardiol. 2022 Feb 22;79(7):632-647. Pubmed
2021
Cytotoxic CD8+ T cells promote granzyme B-dependent adverse post-ischemic cardiac remodeling.
Santos-Zas I, Lemarié J, Zlatanova I, Cachanado M, Seghezzi JC, Benamer H, Goube P, Vandestienne M, Cohen R, Ezzo M, Duval V, Zhang Y, Su JB, Bizé A, Sambin L, Bonnin P, Branchereau M, Heymes C, Tanchot C, Vilar J, Delacroix C, Hulot JS, Cochain C, Bruneval P, Danchin N, Tedgui A, Mallat Z, Simon T, Ghaleh B, Silvestre JS, Ait-Oufella H. Nat Commun. 2021 Mar 5;12(1):1483. Pubmed
Endothelial Cell Indoleamine 2, 3-Dioxygenase 1 Alters Cardiac Function After Myocardial Infarction Through Kynurenine.
Melhem NJ, Chajadine M, Gomez I, Howangyin KY, Bouvet M, Knosp C, Sun Y, Rouanet M, Laurans L, Cazorla O, Lemitre M, Vilar J, Mallat Z, Tedgui A, Ait-Oufella H, Hulot JS, Callebert J, Launay JM, Fauconnier J, Silvestre JS, Taleb S. Circulation. 2021 Feb 9;143(6):566-580. Pubmed
2020
Correa BL, Harane NE, Gomez I, Hocine HR, Vilar J, Desgres M, Bellamy V, Keirththana K, Guillas C, Perotto M, Pidial L, Alayrac P, Tran, T, Tan S, Hamada T, Charron D, Brisson A, Renault NK, Al-daccak R, Menasché P, Silvestre JS. Extracellular vesicles from human cardiovascular progenitors trigger a reparative immune response in infarcted hearts. Cardiovasc Res. 2020 Feb 12:cvaa028. doi: 10.1093/cvr/cvaa028.Pubmed
Reviews - Editorials
Zhang C, Wang FS, Silvestre JS, Arenzana-Seisdedos F, Tang H. Is aberrant CD8+ T cell activation by hypertension associated with cardiac injury in severe cases of COVID-19? Cell Mol Immunol. 2020 Jun;17(6):675-676.Pubmed
2019
Zlatanova I, Pinto C, Bonnin P, Mathieu JRR, Bakker W, Vilar J, Lemitre M, Voehringer D, Vaulont S, Peyssonnaux C, Silvestre JS. The Iron Regulator Hepcidin Impairs Macrophage Dependent Cardiac Repair After Injury. Circulation. 2019 Mar 19;139(12):1530-1547.Pubmed
Reviews - Editorials
Silvestre JS. CCL21 in Acute Coronary Syndromes: Biomarker of the 21st Century?. J Am Coll Cardiol. 2019 Aug 13;74(6):783-785.Pubmed
Silvestre JS, Vandecasteele G. [Heart rate: when macrophages hit the note].Med Sci (Paris). 2018 Oct;34(10):820-823. Pubmed
2018
Loyer X, Zlatanova I, Devue C, Yin M, Howangyin KY, Klaihmon P, Guerin CL, Kheloufi M, Vilar J, Zannis K, Fleischmann BK, Hwang DW, Park J, Lee H, Menasché P, Silvestre JS, Boulanger CM. Intra-Cardiac Release of Extracellular Vesicles Shapes Inflammation Following Myocardial Infarction. Circ Res. 2018 Jun 22;123(1):100-106 . Pubmed
Merkulova-Rainon T, Mantsounga CS, Broquères-You D, Pinto C, Vilar J, Cifuentes D, Bonnin P, Kubis N, Henrion D, Silvestre JS, Lévy BI. Peripheral post-ischemic vascular repair is impaired in a murine model of Alzheimer's disease. Angiogenesis. 2018 Mar 7. doi: 10.1007/s10456-018-9608-7.Pubmed
El Harane N, Kervadec A, Bellamy V, Pidial L, Neametalla HJ, Perier MC, Lima Correa B, Thiébault L, Cagnard N, Duché A, Brunaud C, Lemitre M, Gauthier J, Bourdillon AT, Renault MP, Hovhannisyan Y, Paiva S, Colas AR, Agbulut O, Hagège A, Silvestre JS, Menasché P, Renault NKE. Acellular therapeutic approach for heart failure: in vitro production of extracellular vesicles from human cardiovascular progenitors. Eur Heart J. 2018 Feb 6. doi: 10.1093/eurheartj/ehy012. Pubmed
Reviews - Editorials
Gomez I, Duval V, Silvestre JS. Cardiomyocytes and Macrophages Discourse on the Method to Govern Cardiac Repair. Front Cardiovasc Med. 2018 Oct 2;5:134.Pubmed
Boulanger CM, Silvestre JS, Tedgui A. Cardiovascular Research in France. Circ Res. 2018 Mar 2;122(5):657-660. Pubmed
Annex BH, Silvestre JS. MRP-14 Preach the Worse for Platelets and Monocytes Union in Peripheral Artery Disease. J Am Coll Cardiol. 2018 Jan 2;71(1):66-68. Pubmed
2017
Guerin CL, Rossi E, Saubamea B, Cras A, Mignon V, Silvestre JS, Smadja DM. Human very Small Embryonic-like Cells Support Vascular Maturation and Therapeutic Revascularization Induced by Endothelial Progenitor Cells. Stem Cell Rev. 2017 Aug;13(4):552-560. doi: 10.1007/s12015-017-9731. Pubmed
Guerin CL, Blandinières A, Planquette B, Silvestre JS, Israel-Biet D, Sanchez O, Smadja DM. Very Small Embryonic-like Stem Cells Are Mobilized in Human Peripheral Blood during Hypoxemic COPD Exacerbations and Pulmonary Hypertension. Stem Cell Rev. 2017 Aug;13(4):561-566. Pubmed
Blondiaux E, Pidial L, Autret G, Rahmi G, Balvay D, Audureau E, Wilhelm C, Guerin CL, Bruneval P, Silvestre JS, Menasché P, Clément O. Bone marrow-derived mesenchymal stem cell-loaded fibrin patches act as a reservoir of paracrine factors in chronic myocardial infarction. J Tissue Eng Regen Med. 2017 Dec;11(12):3417-3427. Pubmed
2016
Ngkelo A, Richart A, Kirk JA, Bonnin P, Vilar J, Lemitre M, Marck P, Branchereau M, Le Gall S, Renault N, Guerin C, Ranek MJ, Kervadec A, Danelli L, Gautier G, Blank U, Launay P, Camerer E, Bruneval P, Menasche P, Heymes C, Luche E, Casteilla L, Cousin B, Rodewald HR, Kass DA, Silvestre JS. Mast cells regulate myofilament calcium sensitization and heart function after myocardial infarction. J Exp Med. 2016 Jun 27;213(7):1353-74. Pubmed
Howangyin KY, Zlatanova I, Pinto C, Ngkelo A, Cochain C, Rouanet M, Vilar J, Lemitre M, Stockmann C, Fleischmann BK, Mallat Z, Silvestre JS. Myeloid-Epithelial-Reproductive Receptor Tyrosine Kinase and Milk Fat Globule Epidermal Growth Factor 8 Co-Ordinately Improve Remodeling After Myocardial Infarction via Local Delivery of Vascular Endothelial Growth Factor. Circulation. 2016 Mar 1;133(9):826-39. Pubmed
Kervadec A, Bellamy V, El Harane N, Arakélian L, Vanneaux V, Cacciapuoti I, Nemetalla H, Périer MC, Toeg HD, Richart A, Lemitre M, Yin M, Loyer X, Larghero J, Hagège A, Ruel M, Boulanger CM, Silvestre JS, Menasché P, Renault NK. Cardiovascular progenitor-derived extracellular vesicles recapitulate the beneficial effects of their parent cells in the treatment of chronic heart failure. J Heart Lung Transplant. 2016 Jun;35(6):795-807. Pubmed
Breining A, Silvestre JS, Dieudonné B, Vilar J, Faucounau V, Verny M, Néri C, Boulanger CM, Boddaert J. Biomarkers of vascular dysfunction and cognitive decline in patients with Alzheimer's disease: no evidence for association in elderly subjects. Aging Clin Exp Res. 2016 Jan 23. Pubmed
2015
Lozeron P, Mantsounga CS, Broqueres-You D, Dohan A, Polivka M, Deroide N, Silvestre JS, Kubis N, Lévy BI.Characterization of nerve and microvessel damage and recovery in type 1 diabetic mice after permanent femoral artery ligation. J Neurosci Res. 2015 Sep;93(9):1451-61. PubMed
Boufenzer A, Lemarié J, Simon T, Derive M, Bouazza Y, Tran N, Maskali F, Groubatch F, Bonnin P, Bastien C, Bruneval P, Marie PY, Cohen R, Danchin N, Silvestre JS, Ait-Oufella H, Gibot S. TREM-1 Mediates Inflammatory Injury and Cardiac Remodeling Following Myocardial Infarction. Circ Res. 2015 May 22;116(11):1772-82. PubMed
d'Audigier C, Cochain C, Rossi E, Guérin CL, Bièche I, Blandinières A, Marsac B, Silvestre JS, Gaussem P, Smadja DM. Thrombin receptor PAR-1 activation on endothelial progenitor cells enhances chemotaxis-associated genes expression and leukocyte recruitment by a COX-2-dependent mechanism.Angiogenesis. 2015 Jul;18(3):347-59. PubMed
GuerinCL, Loyer X, Vilar J, Cras A, Mirault T, Gaussem P Silvestre JS, Smadja DM. Bone-marrow-derived very small embryonic-like stem cells in patients with critical leg ischaemia: evidence of vasculogenic potential. Thromb Haemost. 2015 May;113(5):1084-94. PubMed
Reviews - Editorials
Silvestre JS, Planat-Benard V, Casteilla L. Adipose tissue-derived therapeutic cells for peripheral artery diseases: the fatty blessing. Expert Opin Biol Ther. 2016 Jun;16(6):735-8. doi: 10.1080/14712598.2016.1181170. Pubmed
Silvestre JS, Menasché P. The evolution of the stem cell theory for heart failure. EBioMedicine. 2015 Dec;2(12) : 1871-1879. Pubmed
2014
Loinard C, Basatemur G, Masters L, Baker L, Harrison J, Figg N, Vilar J, Sage A, Mallat Z. Deletion of chromosome 9p21 noncoding cardiovascular risk interval in mice alters Smad2 signaling and promotes vascular aneurysm. Circ Cardiovasc Genet. 2014;7:799-805. PubMed
Richart A, Loyer X, Neri T, Howangyin K, Guerin CL, Ngkelo A, Bakker W, Zlatanova I, Rouanet M, Vilar J, Lévy B, Rothenberg M, Mallat Z, Pucéat M, Silvestre JS. MicroRNA-21 coordinates Human multipotent cardiovascular progenitors therapeutic potential. Stem Cells 014 Nov;32(11):2908-22. PubMed
Faye N, Clément O, Balvay D, Fitoussi V, Pidial L, Sandoval F, Autret G, Silvestre JS, Dean CL, Alison M, Fournier LS. Multiparametric optical and MR imaging demonstrate inhibition of tumor angiogenesis natural history by mural cell therapy. Magn Reson Med. 2014 Sep;72(3):841-9. PubMed
Pichon A, Lamarre Y, Voituron N, Marchant D, Vilar J, Richalet JP, Connes P. Red blood cell deformability is very slightly decreased in erythropoietin deficient mice. Clin Hemorheol Microcirc. 2014;56(1):41-6. PubMed
Bura A, Planat-Benard V, Bourin P, Silvestre JS, Gross F, Grolleau JL, Saint-Lebese B, Peyrafitte JA, Fleury S, Gadelorge M, Taurand M, Dupuis-Coronas S, Leobon B, Casteilla L. Phase I trial: the use of autologous cultured adipose-derived stroma/stem cells to treat patients with non-revascularizable critical limb ischemia. Cytotherapy. 2014 Feb;16(2):245-57. PubMed
Howangyin KY, Loinard C, Bakker W, Guérin CL, Vilar J, D'Audigier C, Mauge L, Bruneval P, Emmerich J, Lévy B, Pouysségur J, Smadja DM, Silvestre JS. HIF-prolyl hydroxylase 2 inhibition enhances the efficiency of mesenchymal stem cells-based therapies for the treatment of critical limb ischemia. Stem Cells 2014 Jan;32(1):231-43. PubMed
Pichon A, Lamarre Y, Voituron N, Marchant D, Vilar J, Richalet JP, Connes P. Red blood cell deformability is very slightly decreased in erythropoietin deficient mice. Clin Hemorheol Microcirc. 2014;56(1):41-6. PubMed
Bura A, Planat-Benard V, Bourin P, Silvestre JS, Gross F, Grolleau JL, Saint-Lebese B, Peyrafitte JA, Fleury S, Gadelorge M, Taurand M, Dupuis-Coronas S, Leobon B, Casteilla L. Phase I trial: the use of autologous cultured adipose-derived stroma/stem cells to treat patients with non-revascularizable critical limb ischemia. Cytotherapy. 2014 Feb;16(2):245-57. PubMed
Howangyin KY, Loinard C, Bakker W, Guérin CL, Vilar J, D'Audigier C, Mauge L, Bruneval P, Emmerich J, Lévy B, Pouysségur J, Smadja DM, Silvestre JS. HIF-prolyl hydroxylase 2 inhibition enhances the efficiency of mesenchymal stem cells-based therapies for the treatment of critical limb ischemia. Stem Cells 2014 Jan;32(1):231-43. PubMed
Reviews - Editorials
Howangyin KY, Silvestre JS. Diabetes mellitus and ischemic diseases: molecular mechanisms of vascular repair dysfunction. Arterioscler Thromb Vasc Biol. 2014 Jun;34(6):1126-35. PubMed
Silvestre JS. When the vessels use their brain for therapeutic revascularization. Arterioscler Thromb Vasc Biol. 2014 Feb;34(2):237-8. PubMed
2013
Avraham-Davidi I, Yona S, Grunewald M, Landsman L, Cochain C, Silvestre JS, Mizrahi H, Faroja M, Strauss-Ayali D, Mack M, Jung S, Keshet E. On-site education of VEGF-recruited monocytes improves their performance as angiogenic and arteriogenic accessory cells. J Exp Med. 2013 Nov 18;210(12):2611-25. PubMed
Blondiaux E, Pidial L, Vilar J, Autret G, Balvay D, Audureau E, Bruneval P, Bel A, Cuenod CA, Silvestre JS, Clément O. Evaluation of Rat Heart Microvasculature with High-Spatial-Resolution Susceptibility-weighted MR Imaging. Radiology. 2013 Oct;269(1):277-82. PubMed
Zouggari Y, Ait-Oufella H, Bonnin P, Simon T, Sage AP, Guérin G, Vilar J, Caligiuri G, Tsiantoulas D, Laurans L, Dumeau E, Kotti K, Bruneval K, Charo IF, Binder CJ, Danchin N, Tedgui A, Tedder TF, Silvestre JS*/Mallat Z*. B lymphocytes trigger Ccl7-dependent mobilization of monocytes and promote adverse ventricular remodeling after acute myocardial infarction. Nat Med. 2013. Oct;19(10):1273-80. PubMed
Foubert P, Squiban C, Holler V, Buard V, Dean C, Levy B, Benderitter M, Silvestre J, Tobelem G, Tamarat R. Strategies to enhance the efficiency of endothelial progenitor cell therapy by Ephrin B2 pre-treatment and Co administration with Smooth Muscle Progenitor Cells on vascular function during wound healing process in irradiated or not condition. Cell Transplant. 2013 Sep 10. doi: 10.3727/096368913X672064. PubMed
Reviews - Editorials
Silvestre JS, Smadja DM, Lévy BI. Post-ischemic revascularization : from cellular and molecular mechanisms to clinical applications. Physiol Rev. 2013 Oct;93(4):1743-802. PubMed
Smadja D, Silvestre JS, Lévy BI. Genic and cellular therapy for peripheral arterial diseases. Transfus Clin Biol. 2013 May;20(2):211-20. PubMed
Silvestre JS. Vascular endothelial growth factor and angiogenesis: the XBP1 games. Circulation. 2013 Apr 23;127(16):1644-6. PubMed
Cochain C, Channon KM, Silvestre JS. Angiogenesis in the infarcted myocardium. Antioxid Redox Signal. 2013 Mar 20 ;18(9) :1100-13. PubMed
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